The last part of chapter 11 gives a brief history of Abram's family. His father Terah, from Chaldea, set out to go to Canaan with his sons and their wives. They settled mid-way at Harran.
Chapter 12 introduces God's calling of Abram, who did not have much significance until then. God commanded him to leave his father's house, the place of comfort, and follow God's guidance to the land of His promise. God's promise for Abram: to make him a source of blessing to all peoples on earth, and whoever curses Abram would bear God's curse (3). God was inviting Abram to leave his comfort zone and take a place on God's side under his protection (Isaiah 41:10).
Abram responded to the call by simply obeying. He took his household and traveled to Canaan as God showed him. Abram was not discouraged by the fact that people already occupied the land. He trusted God's presence (7) and believed the promise that his descendants would occupy the land. Moreover, he understood the weight of God's covenant and cherished the eternal kingdom God would bring to the whole earth, beginning with Abram himself (Heb 11:10).
Application: Father, thank you for calling Abram to be a blessing. I pray to respond to your call with my trust in your perfect and good plan.
One Word: So Abram went